Which Statins Need To Be Taken At Night

December 06, 2021

Which Statins Need To Be Taken At Night

Zocor is reported to take in evening. Lipitor belongs to a group of prescription medicines called statins.

1 Part 5 Agents Used In Hyperlipidemia Weiping Zhang Md Ph D Department Of Pharmacology Zhejiang University School Of Medicine Pharmacology For Ppt Download

This is more so with earlier drugs like lovastatin which were shorter acting than atorvastatin.

Which statins need to be taken at night. On the other hand long acting statins can be taken at any time of the day. These statins are best taken at night. Check with your doctor whether theres a particular time of day you should take your statin.

If a statin has a half life of less than 6 hours it should be taken at night. Pravachol crestor and Lipitor atorvastatin can be taken at any time. Short-acting statins are most effective when a person takes them at night but a person can take long-acting statins at any time of the day.

The elimination half-lives of statins determine if an agent should be dosed at bedtime. Some common statins are. Short acting statins should be taken at night because the liver produces high levels of cholesterol at midnight.

The enzyme is more active at night. Blood cholesterol may come from foods that are high in fat and is also produced by some of our bodys organs most of this production is at night between 1200 am and 600 am. This is why statins are most effective when taken at night.

Since atorvastatin is a long acting drug it will have its effect even if it is taken. These drugs lower cholesterol and improve cardiovascular outcomes by decreasing the amount of cholesterol our body produces as well as reducing inflammation in blood vessels. In this literature review the only statistically significant conclusion was that simvastatin should be taken in the evening to optimize the reduction of LDL-C levels.

Statins that you should take at night. If they are taken early in the day the effectiveness will be reduced. Studies show that when simvastatin is taken at night theres a greater reduction in LDL cholesterol than when its taken in the morning.

Simvastatin Zocor lovastatin Altoprev Mevacor f luvastatin Lescol XL atorvastatin Lipitor pitavastatin Livalo pravastatin Pravachol rosuvastatin Crestor. Answered on Feb 18 2020. As a reminder thats lovastatin simvastatin pravastatin fluvastatin.

So it is better to take statins at night. For example simvastatin is a good example of a statin that works most efficiently if its taken in the evening. You usually have to continue taking statins for life because if you stop taking them your cholesterol will return to a high level within a few weeks.

Well cover your options in detail. Take atorvastatin once a day. Cholesterol synthesis appears to occur mostly at night so statins with short half-lives are usually taken at night to maximize their effect.

Which one is most appropriate if you live with diabetes. Simvastatin Zocor lovastatin Altoprev Mevacor fluvastatin Lescol XL atorvastatin Lipitor pitavastatin Livalo pravastatin Pravachol rosuvastatin Crestor. Studies have shown that there is a higher reduction in LDL cholesterol levels when simvastatin is taken at night when compared to this statin taken in the morning.

Some statins that have a longer time in the blood so less of an issue. Some common statins are. Some types of statin should be taken in the evening.

Statins can be effective at lowering LDL or bad cholesterol. So the FDA took this pharmacokinetic logic to heart haha and specifically recommends taking the short acting statins at night. Simvastatin lovastatin pravastatin atorvastatin are the first-choice treatments for preventing CVD when high blood cholesterol exists.

The half-lives of some statins are even less than six hours. The half life of Lipitor is 14 hours and its active metabolites up to 20 to 30 hours therefore Lipitor can be taken at anytime. Drugs which inhibit it will have better effect when taken at night.

Meaning if you take short acting statins in the morning their effect wears off by night-time when your peak lipid synthesis happens. To maximize the effects of statins with a short half-life fluvastatin lovastatin and simvastatin should be dosed at bedtime allowing the greatest drug concentration to be present during peak. According to their fda package inserts.

Some statins have half-lives of less than six hours. Simvastatin is an example of a statin that works better if taken in the evening. Lipitor Atorvastatin is a statin medication that belongs to a class of drugs known as HMG-CoA Reductase Inhibitors.

Sometimes doctors may recommend taking it in the evening. Short-acting statins which have half-lives around 6 hours are therefore more effective when taken in the evening. Statins - cholesterol-lowering drugs - eg.

Simvastatin Zocor Pravastatin Pravachol Fluvastatin standard release Lovastatin Mevacor By their very nature long-acting statins exert effects over a longer period and so can be taken either in the morning or evening. You can choose to take it at any time as long as you stick to the same time every day. Why Should I Take Lipitor Atorvastatin At Night.

If youre not sure when to take your medicine ask a pharmacist or your doctor for advice. This is because your body makes most cholesterol at night. However they should be.

Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning 125 126 but have shown no difference in the long-acting atorvastatin.

Why Are Statins Taken At Night